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Description

NLRP3 inflammasome activation triggers Caspase-1-mediated mitochondrial damage, characterized by increased mtROS production, mitochondrial swelling, and fragmentation, while also inhibiting mitophagy and amplifying mitochondrial damage [11]

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Overproduction of ROS and low levels or deactivation of antioxidant machinery causes increased oxidative stress in cancer cells

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Dong D, Zielke HR, Yeh D, Yang P

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